Dietary Leucine: An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism | June 2011

Articles

PLOS ONE

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021187

Supplementing Breakfast with a Vitamin D and Leucine-Enriched Whey Protein Medical Nutrition Drink Enhances Postprandial Muscle Protein Synthesis and Muscle Mass in Healthy Older Men | August 2017

Articles

Journal of Nutrition

https://doi.org/10.3945/jn.117.252510

A Focus on Leucine in the Nutritional Regulation of Human Skeletal Muscle Metabolism in Ageing, Exercise and Unloading States | August 2023

Articles

Clinical Nutrition

https://www.sciencedirect.com/science/article/pii/S0261561423002583

Leucine-Rich Diet Modulates the Metabolomic and Proteomic Profile of Skeletal Muscle during Cancer Cachexia | July 2020

Articles

Cancers

https://doi.org/10.3390/cancers12071880

Leucine and Perindopril to Improve Physical Performance in People Over 70 Years with Sarcopenia: The LACE Factorial RCT | August 2022

Publications (Books-Reports)

National Institute for Health and Care Research

https://doi.org/10.3310/LLBX6901

Metabolic and Molecular Responses to Leucine-Enriched Branched Chain Amino Acid Supplementation in the Skeletal Muscle of Alcoholic Cirrhosis | February 2015

Articles (Manuscripts-Versions)

PubMed Central>Hepatology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441611/

An Update on Protein, Leucine, Omega-3 Fatty Acids, and Vitamin D in the Prevention and Treatment of Sarcopenia and Functional Decline | August 2018

Articles

Nutrients

https://www.mdpi.com/2072-6643/10/8/1099

Enriching a Protein Drink with Leucine Augments Muscle Protein Synthesis After Resistance Exercise in Young and Older Men | April 2016

Abstracts

Clinical Nutrition

https://www.sciencedirect.com/science/article/pii/S0261561416300711

Effects of Leucine-Enriched Whey Protein Supplementation on Physical Function in Post-Hospitalized Older Adults Participating in 12-Weeks of Resistance Training Program: A Randomized Controlled Trial | October 2019

Articles

Nutrients

https://www.mdpi.com/2072-6643/11/10/2337

Combining Phenylalanine and Leucine Levels Predicts 30-Day Mortality in Critically Ill Patients Better than Traditional Risk Factors with Multicenter Validation | January 2023

Articles

Nutrients

https://www.mdpi.com/2072-6643/15/3/649

Reviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis | May 2015

Articles

Nutrients

https://www.mdpi.com/2072-6643/7/5/3914

Evaluating the Leucine Trigger Hypothesis to Explain the Post-Prandial Regulation of Muscle Protein Synthesis in Young and Older Adults: A Systematic Review | July 2021

Articles

Frontiers in Nutrition

https://www.frontiersin.org/articles/10.3389/fnut.2021.685165/full

Quick and Effective Improvement of Leucine Enriched Dietary Supplement on Malnutrition in Acute Stroke Patients Receiving Enteral Tube Feeding | July 2020

Articles

BMC Emergency Medicine

https://bmcemergmed.biomedcentral.com/articles/10.1186/s12873-020-00351-w

Novel Essential Amino Acid Supplements Enriched with L-Leucine Facilitate Increased Protein and Energy Intakes in Older Women: A Randomised Controlled Trial | November 2017

Articles

Nutrition Journal

https://nutritionj.biomedcentral.com/articles/10.1186/s12937-017-0298-6

Postprandial Muscle Protein Synthesis Is Higher After a High Whey Protein, Leucine-Enriched Supplement than After a Dairy-Like Product in Healthy Older People: A Randomized Controlled Trial | January 2014

Articles

Nutrition Journal

https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-9

Activation of mTORC1 by Leucine Is Potentiated by Branched-Chain Amino Acids and Even More So by Essential Amino Acids Following Resistance Exercise | June 2016

Articles

American Journal of Physiology-Cell Physiology

https://journals.physiology.org/doi/full/10.1152/ajpcell.00374.2015

Endurance Exercise Training Attenuates Leucine Oxidation and BCOAD Activation during Exercise in Humans | April 2000

Articles

American Journal of Physiology-Endocrinology and Metabolism

https://journals.physiology.org/doi/full/10.1152/ajpendo.2000.278.4.E580

Protective Effects of Glutamine and Leucine Supplementation on Sepsis-Induced Skeletal Muscle Injuries | November 2021

Articles

International Journal of Molecular Sciences

https://www.mdpi.com/1422-0067/22/23/13003

Deficiency in the Essential Amino Acids L-Isoleucine, L-Leucine and L-Histidine and Clinical Measures as Predictors of Moderate Depression in Elderly Women: A Discriminant Analysis Study | October 2021

Articles

Nutrients

https://www.mdpi.com/2072-6643/13/11/3875

Medium-Chain Triglycerides in Combination with Leucine and Vitamin D Increase Muscle Strength and Function in Frail Elderly Adults in a Randomized Controlled Trial | April 2016

Articles

Journal of Nutrition

http://dx.doi.org/10.3945/jn.115.228965

Leucine Metabolism in Regulation of Insulin Secretion from Pancreatic Beta Cells | May 2010

Articles (Manuscripts-Versions)

PubMed Central>Nutrition Reviews

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2969169/

Effects of Whey, Soy or Leucine Supplementation with 12 Weeks of Resistance Training on Strength, Body Composition, and Skeletal Muscle and Adipose Tissue Histological Attributes in College-Aged Males | September 2017

Articles

Nutrients

https://www.mdpi.com/2072-6643/9/9/972

Leucine Is a Major Regulator of Muscle Protein Synthesis in Neonates | November 2014

Articles (Manuscripts-Versions)

PubMed Central>Amino Acids

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304911/

The Role of Leucine in Weight Loss Diets and Glucose Homeostasis | January 2003

Articles

Journal of Nutrition

https://doi.org/10.1093/jn/133.1.261S

Co-Ingestion of a Protein Hydrolysate with or without Additional Leucine Effectively Reduces Postprandial Blood Glucose Excursions in Type 2 Diabetic Men | May 2006

Articles

Journal of Nutrition

https://doi.org/10.1093/jn/136.5.1294

The Role of Leucine in the Regulation of Protein Metabolism | June 2005

Articles

Journal of Nutrition

https://doi.org/10.1093/jn/135.6.1553S

Leucine Supplementation Increases Muscle Strength and Volume, Reduces Inflammation, and Affects Wellbeing in Adults and Adolescents with Cerebral Palsy | January 2020

Articles

Journal of Nutrition

https://doi.org/10.1093/jn/nxaa006

The Effect of Leucine Supplementation on Sarcopenia-Related Measures in Older Adults: A Systematic Review and Meta-Analysis of 17 Randomized Controlled Trials | July 2022

Articles

Frontiers in Nutrition

https://www.frontiersin.org/articles/10.3389/fnut.2022.929891/full

Whole Body Protein Anabolism in COPD Patients and Healthy Older Adults Is Not Enhanced by Adding Either Carbohydrates or Leucin to a Serving of Protein | August 2018

Articles (Manuscripts-Versions)

PubMed Central>Clinical Nutrition

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377853/

Leucine Regulates Translation Initiation of Protein Synthesis in Skeletal Muscle After Exercise | February 2006

Articles

Journal of Nutrition

https://doi.org/10.1093/jn/136.2.533S

Impact of Exercise and Leucine-Enriched Protein Supplementation on Physical Function, Body Composition, and Inflammation in Pre-Frail Older Adults: A Quasi-Experimental Study | August 2023

Articles

Frontiers in Medicine

https://www.frontiersin.org/articles/10.3389/fmed.2023.1204198/full

Leucine-Enriched Nutrients and the Regulation of Mammalian Target of Rapamycin Signalling and Human Skeletal Muscle Protein Synthesis | May 2008

Articles (Manuscripts-Versions)

PubMed Central>Current Opinion in Clinical Nutrition and Metabolic Care

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096790/

Effects of a Vitamin D and Leucine-Enriched Whey Protein Nutritional Supplement on Measures of Sarcopenia in Older Adults, the PROVIDE Study: A Randomized, Double-Blind, Placebo-Controlled Trial | July 2015

Articles

Journal of the American Medical Directors Association

https://www.sciencedirect.com/science/article/pii/S1525861015003886

Whey Protein, Leucine- and Vitamin-D-Enriched Oral Nutritional Supplementation for the Treatment of Sarcopenia | April 2022

Articles

Nutrients

https://www.mdpi.com/2072-6643/14/7/1524

Leucine-Enriched Nutrients and the Regulation of mTOR Signalling and Human Skeletal Muscle Protein Synthesis | May 2008

Articles (Manuscripts-Versions)

PubMed Central>Current Opinion in Clinical Nutrition and Metabolic Care

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096790/

Similar Effects of Leucine Rich and Regular Dairy Products on Muscle Mass and Functions of Older Polymyalgia Rheumatica Patients: A Randomized Crossover Trial | October 2010

Abstracts

Journal of Nutrition, Health and Aging

https://link.springer.com/article/10.1007/s12603-010-0276-6

Leucine, Not Total Protein, Content of a Supplement Is the Primary Determinant of Muscle Protein Anabolic Responses in Healthy Older Women | June 2018

Articles

Journal of Nutrition

https://doi.org/10.1093/jn/nxy091

Anabolic Effects of Oral Leucine-Rich Protein with and without B-Hydroxybutyrate on Muscle Protein Metabolism in a Novel Clinical Model of Systemic Inflammation: A Randomized Crossover Trial | June 2021

Articles

American Journal of Clinical Nutrition

https://doi.org/10.1093/ajcn/nqab148

Leucine Partially Protects Muscle Mass and Function during Bed Rest in Middle-Aged Adults | December 2015

Articles

American Journal of Clinical Nutrition

https://doi.org/10.3945/ajcn.115.112359

Effects of Resistance Training Using Elastic Bands on Muscle Strength with or without a Leucine Supplement for 48 Weeks in Elderly Patients with Type 2 Diabetes | October 2020

Articles

Endocrine Journal

https://doi.org/10.1507/endocrj.EJ20-0550

Tyrosine Is a Booster of Leucine-Induced Muscle Anabolic Response | December 2023

Articles

Nutrients

https://www.mdpi.com/2072-6643/16/1/84

Knowledge Gained from Studies of Leucine Consumption in Animals and Humans | October 2012

Articles

Journal of Nutrition

https://doi.org/10.3945/jn.111.157370

Targeting Inflammation and Downstream Protein Metabolism in Sarcopenia: A Brief Up-Dated Description of Concurrent Exercise and Leucine-Based Multimodal Intervention | June 2017

Articles

Frontiers in Physiology

https://www.frontiersin.org/articles/10.3389/fphys.2017.00434/full

Age and Sex Affect Protein Metabolism at Protein Intakes that Span the Range of Adequacy: Comparison of Leucine Kinetics and Nitrogen Balance Data | July 2012

Articles (Manuscripts-Versions)

PubMed Central>Journal of Nutritional Biochemistry

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885868/

Standard Hypercaloric, Hyperproteic vs. Leucine-Enriched Oral Supplements in Patients with Cancer-Induced Sarcopenia, a Randomized Clinical Trial | June 2023

Articles

Nutrients

https://www.mdpi.com/2072-6643/15/12/2726

Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus Paracasei PS23 for the Treatment of Sarcopenia in Elderly Subjects: A 2-Month Randomized Double-Blind Placebo-Controlled Trial | October 2022

Articles

Nutrients

https://www.mdpi.com/2072-6643/14/21/4566

Human Skeletal Muscle Is Refractory to the Anabolic Effects of Leucine during the Postprandial Muscle-Full Period in Older Men | October 2017

Articles

NCBI>Clinical Science

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869244/

Gender Differences in Leucine, But Not Lysine, Kinetics | July 2001

Articles

Journal of Applied Physiology

https://journals.physiology.org/doi/full/10.1152/jappl.2001.91.1.357

High-Protein Diet with Excess Leucine Prevents Inactivity-Induced Insulin Resistance in Women | November 2023

Abstracts

Clinical Nutrition

https://www.sciencedirect.com/science/article/abs/pii/S0261561423003588

Native Whey Induces Similar Adaptation to Strength Training as Milk, Despite Higher Levels of Leucine, in Elderly Individuals | September 2019

Articles

Nutrients

https://www.mdpi.com/2072-6643/11/9/2094